Extensive Cell Movements Accompany Formation of the Otic Placode
نویسندگان
چکیده
منابع مشابه
Zebrafish foxi1 mediates otic placode formation and jaw development.
The otic placode is a transient embryonic structure that gives rise to the inner ear. Although inductive signals for otic placode formation have been characterized, less is known about the molecules that respond to these signals within otic primordia. Here, we identify a mutation in zebrafish, hearsay, which disrupts the initiation of placode formation. We show that hearsay disrupts foxi1, a fo...
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other ions transepithelially with a suite of pumps and transporters, how these proton-secreting cells (PSCs) arise developmentally is unknown. Here, we identify a cell type in the X. laevis larval that expresses a collection of transporters strikingly similar to those observed in the mammalian kidney, including “kidney”-specific isoforms of the H+V-ATPase and Cl−/HCO3− antiporters related to pe...
متن کاملFgf3 and Fgf8 are required together for formation of the otic placode and vesicle.
Fgf3 has long been implicated in otic placode induction and early development of the otocyst; however, the results of experiments in mouse and chick embryos to determine its function have proved to be conflicting. In this study, we determined fgf3 expression in relation to otic development in the zebrafish and used antisense morpholino oligonucleotides to inhibit Fgf3 translation. Successful kn...
متن کاملThe first steps towards hearing: mechanisms of otic placode induction.
The entire inner ear, together with the neurons that innervate it, derive from a simple piece of ectoderm on the side of the embryonic head the otic placode. In this review, we describe the current state of the field of otic placode induction. Several lines of evidence suggest that all craniofacial sensory organs, including the inner ear, derive from a common "pre-placodal region" early in deve...
متن کاملThe epigenetic modifier DNMT3A is necessary for proper otic placode formation.
Cranial placodes are thickenings in the ectoderm that give rise to sensory organs and peripheral ganglia of the vertebrate head. At gastrula and neurula stages, placodal precursors are intermingled in the neural plate border with future neural and neural crest cells. Here, we show that the epigenetic modifier, DNA methyl transferase (DNMT) 3A, expressed in the neural plate border region, influe...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2002
ISSN: 0012-1606
DOI: 10.1006/dbio.2002.0739